The closure of Runway 4/22 at LaGuardia Airport is expected to cause significant disruptions, including extensive flight delays and cancellations. With only one operational runway, the airport's capacity to handle takeoffs and landings is severely limited. The forecasted thunderstorms may further impact air traffic, as air traffic controllers often slow or halt flights during adverse weather. Travelers are advised to check with their airlines for the latest updates and prepare for potential travel disruptions.